The Argentine GP’s FP1 session started with the track surface still dirty, but Marc Márquez recorded the fastest time. Johann Zarco finished in second place, followed by Álex Márquez in third, Franco Morbidelli in fourth, Marco Bezzecchi in fifth, Luca Marini in sixth, Jack Miller in seventh, Maverick Viñales in eighth, Joan Mir in ninth, and Pedro Acosta rounding out the top ten.
| Position | Rider | Team | Time |
|---|---|---|---|
| 1 | Marc Márquez | Ducati Lenovo Team | 1:38.937 |
| 2 | Johann Zarco | Castrol Honda LCR | +0.026 |
| 3 | Álex Márquez | BK8 Gresini Racing MotoGP | +0.271 |
| 4 | Franco Morbidelli | Yamaha Factory Racing | +0.372 |
| 5 | Marco Bezzecchi | Aprilia Racing Team | +0.462 |
| 6 | Luca Marini | Mooney VR46 Racing Team | +0.514 |
| 7 | Jack Miller | Red Bull KTM Factory Racing | +0.528 |
| 8 | Maverick Viñales | KTM Factory Racing | +0.532 |
| 9 | Pedro Acosta | KTM RC 16 | +0.590 |
| 10 | Fabio Quartararo | Yamaha Factory Racing | +0.612 |